Suoqin Jin

Oct 9, 2024 | nature.com | Mengting Chen |Peijie Zhou |Suoqin Jin |Mei Wang |Qing Nie |Ben Wang | +1 more

AbstractRosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female rosacea patients and healthy individuals. Among keratinocytes, a subpopulation characterized by IFNγ-mediated barrier function damage is found to be unique to rosacea lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes and skin barrier damage in mice.

Sep 17, 2024 | nature.com | Suoqin Jin |Maksim V. Plikus |Qing Nie

AbstractRecent advances in single-cell sequencing technologies offer an opportunity to explore cell–cell communication in tissues systematically and with reduced bias. A key challenge is integrating known molecular interactions and measurements into a framework to identify and analyze complex cell–cell communication networks.

Nov 5, 2023 | biorxiv.org | Suoqin Jin |Maksim V. Plikus |Qing Nie

AbstractRecent advances in single-cell sequencing technologies offer an opportunity to explore cell-cell communication in tissues systematically and with reduced bias. A key challenge is the integration between known molecular interactions and measurements into a framework to identify and analyze complex cell-cell communication networks.

Aug 2, 2023 | frontiersin.org | Aflac Cancer |Ying Zhu |Yang Xiao |Suoqin Jin

1 IntroductionRecent advances in single-cell microfluidic technologies have resulted in a ubiquitous implementation of single-cell approaches to understand disease mechanisms and developmental biology (1–3). Single-cell assays provide high-resolution measurement of cell types/subtypes (4) and their molecular states associated with health/disease conditions (5).

Jun 21, 2023 | nature.com | Xiaojie Wang |Raul Ramos |Anne Phan |Jessica L. Flesher |Suoqin Jin |Nitish Shettigar | +13 more

AbstractNiche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity.