Agustin Gonzalez-Vicente

Dec 22, 2023 | biorxiv.org | Ronghao Zhang |Benjamin Kramer |Benjamin Krämer |Agustin Gonzalez-Vicente |Darshan Aatmaram Jadhav

AbstractSingle-cell RNA sequencing (scRNAseq) is a crucial tool in kidney research. These technologies cluster cells according to transcriptome similarity, irrespective of the anatomical location and ordering within the nephron. Thus, a cluster transcriptome may obscure heterogeneity of the cell population within a nephron segment. Elevated dietary fructose leads to salt-sensitive hypertension, in part by fructose reabsorption in the proximal tubule (PT).