Akira Narita

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Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses - Nature Genetics

Jun 11, 2024 | nature.com | Shinichi Namba |Ken Suzuki |Kenichi Yamamoto |Kyuto Sonehara |Akira Narita |Yoichiro Kamatani | +3 more

AbstractType 2 diabetes (T2D) shows heterogeneous body mass index (BMI) sensitivity. Here, we performed stratification based on BMI to optimize predictions for BMI-related diseases. We obtained BMI-stratified datasets using data from more than 195,000 individuals (nT2D = 55,284) from BioBank Japan (BBJ) and UK Biobank. T2D heritability in the low-BMI group was greater than that in the high-BMI group.

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