Ken Suzuki

Nov 11, 2024 | nature.com | Kenichi Yamamoto |Shinichi Namba |Kyuto Sonehara |Ken Suzuki |Saori Sakaue |Koichi Matsuda | +2 more

AbstractThe tripartite ancestral structure is a recently proposed model for the genetic origin of modern Japanese, comprising indigenous Jomon hunter-gatherers and two additional continental ancestors from Northeast Asia and East Asia. To investigate the impact of the tripartite structure on genetic and phenotypic variation today, we conducted biobank-scale analyses by merging Biobank Japan (BBJ; n = 171,287) with ancient Japanese and Eurasian genomes (n = 22).

Sep 20, 2024 | nature.com | Tatsuhiko Naito |Shinichi Namba |Kyuto Sonehara |Ken Suzuki |Biobank Japan |Koichi Matsuda | +2 more

AbstractAlthough polygenic risk scores (PRSs) are expected to be helpful in precision medicine, it remains unclear whether high-PRS groups are more likely to benefit from preventive interventions for diseases. Recent methodological advancements enable us to predict treatment effects at the individual level. We employed causal forest to explore the relationship between PRSs and individual risk of diseases associated with certain environmental factors.

Jun 11, 2024 | nature.com | Shinichi Namba |Ken Suzuki |Kenichi Yamamoto |Kyuto Sonehara |Akira Narita |Yoichiro Kamatani | +3 more

AbstractType 2 diabetes (T2D) shows heterogeneous body mass index (BMI) sensitivity. Here, we performed stratification based on BMI to optimize predictions for BMI-related diseases. We obtained BMI-stratified datasets using data from more than 195,000 individuals (nT2D = 55,284) from BioBank Japan (BBJ) and UK Biobank. T2D heritability in the low-BMI group was greater than that in the high-BMI group.

May 20, 2024 | digitalcommons.library.tmc.edu | Ken Suzuki |Konstantinos Hatzikotoulas |Lorraine Southam |Henry Taylor

AbstractType 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D.