Albert J.R. Heck

Oct 17, 2024 | biorxiv.org | Jo H. Judernatz |Tereza Kadavà |Albert J.R. Heck |Laura Perez Paneda

AbstractThe manchette is a transient microtubule based structure that plays a vital role in nuclear shaping during spermiogenesis. It comprises thousands of microtubules (MTs) that build a scaffold around the distal half of the nucleus. The manchette distributes proteins and vesicles during spermiogenesis in a process called intra-manchette transport (IMT).

Oct 19, 2023 | biorxiv.org | Wouter van Bergen |Jan Fiala |Albert J.R. Heck |Marc baggelaar

AbstractComparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-targets, in complex proteomes is crucial for selecting optimal drug candidates. The affinity of small molecules for targeted proteins is largely dictated by interactions between amino acid side chains and these drugs. Thus, studying drug-protein interactions at an amino acid resolution provides a comprehensive understanding of drug selectivity and efficacy.