Marc baggelaar

Oct 19, 2023 | biorxiv.org | Wouter van Bergen |Jan Fiala |Albert J.R. Heck |Marc baggelaar

AbstractComparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-targets, in complex proteomes is crucial for selecting optimal drug candidates. The affinity of small molecules for targeted proteins is largely dictated by interactions between amino acid side chains and these drugs. Thus, studying drug-protein interactions at an amino acid resolution provides a comprehensive understanding of drug selectivity and efficacy.