Albert J Seo

Apr 2, 2024 | biorxiv.org | Amin Addetia |Cameron Stewart |Albert J Seo |Kaitlin R Sprouse

AbstractMiddle-East respiratory syndrome coronavirus (MERS-CoV) first emerged in 2012 and causes human infections in endemic regions. Most vaccines and therapeutics in development against MERS-CoV focus on the spike (S) glycoprotein to prevent viral entry into target cells. These efforts, however, are limited by a poor understanding of antibody responses elicited by infection along with their durability, fine specificity and contribution of distinct S antigenic sites to neutralization.

Mar 14, 2024 | cell.com | M. Alejandra Tortorici |Amin Addetia |Albert J Seo |Jack Brown

Highlights•XBB.1.5 COVID-19 mRNA vaccine elicits neutralizing antibodies against current variants•Depletion of Wuhan-Hu-1 S-reactive plasma antibodies abrogate XBB.1.5 neutralization•XBB.1.5 COVID-19 mRNA vaccine primary recalls Wuhan-Hu-1 S-reactive memory B cellsSummaryImmune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains.

Mar 14, 2024 | shorturl.at | M. Alejandra Tortorici |Amin Addetia |Albert J Seo |Jack Brown

Highlights•XBB.1.5 COVID-19 mRNA vaccine elicits neutralizing antibodies against current variants•Depletion of Wuhan-Hu-1 S-reactive plasma antibodies abrogate XBB.1.5 neutralization•XBB.1.5 COVID-19 mRNA vaccine primary recalls Wuhan-Hu-1 S-reactive memory B cellsSummaryImmune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains.

Nov 30, 2023 | biorxiv.org | M. Alejandra Tortorici |Amin Addetia |Jack Brown |Albert J Seo

AbstractImmune imprinting - also known as original antigenic sin describes how the first exposure a virus shapes the immunological outcome of subsequent exposures to antigenically related strains. SARS-CoV-2 Omicron breakthrough infections and bivalent COVID-19 vaccination were shown to primarily recall cross-reactive memory B cells and antibodies induced by prior mRNA vaccination with the Wuhan-Hu-1 spike rather than priming naive B cells that recognize Omicron-specific epitopes.