M. Alejandra Tortorici

Aug 26, 2024 | biorxiv.org | M. Alejandra Tortorici |Jimin Lee |Anette Choi |Cecily Gibson

AbstractThe ability of coronaviruses to recombine and cross species barriers affects human and animal health globally and is a pandemic threat. FCoV-23 is a recently emerged, highly pathogenic recombinant coronavirus responsible for a widespread outbreak of feline infectious peritonitis (FIP) likely linked to in-host viral evolution.

Mar 14, 2024 | cell.com | M. Alejandra Tortorici |Amin Addetia |Albert J Seo |Jack Brown

Highlights•XBB.1.5 COVID-19 mRNA vaccine elicits neutralizing antibodies against current variants•Depletion of Wuhan-Hu-1 S-reactive plasma antibodies abrogate XBB.1.5 neutralization•XBB.1.5 COVID-19 mRNA vaccine primary recalls Wuhan-Hu-1 S-reactive memory B cellsSummaryImmune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains.

Mar 14, 2024 | shorturl.at | M. Alejandra Tortorici |Amin Addetia |Albert J Seo |Jack Brown

Highlights•XBB.1.5 COVID-19 mRNA vaccine elicits neutralizing antibodies against current variants•Depletion of Wuhan-Hu-1 S-reactive plasma antibodies abrogate XBB.1.5 neutralization•XBB.1.5 COVID-19 mRNA vaccine primary recalls Wuhan-Hu-1 S-reactive memory B cellsSummaryImmune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains.

Nov 30, 2023 | biorxiv.org | M. Alejandra Tortorici |Amin Addetia |Jack Brown |Albert J Seo

AbstractImmune imprinting - also known as original antigenic sin describes how the first exposure a virus shapes the immunological outcome of subsequent exposures to antigenically related strains. SARS-CoV-2 Omicron breakthrough infections and bivalent COVID-19 vaccination were shown to primarily recall cross-reactive memory B cells and antibodies induced by prior mRNA vaccination with the Wuhan-Hu-1 spike rather than priming naive B cells that recognize Omicron-specific epitopes.