Amin Addetia

Jan 15, 2025 | biorxiv.org | Risako Gen |Amin Addetia |Daniel Asarnow |Young-Jun Park

AbstractSARS-CoV-2 nonstructural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 in other host species remains elusive, especially in bats which are natural reservoirs of sarbecoviruses and possess a markedly different innate immune system than humans. Here, we reveal that SARS-CoV-2 nsp1 potently inhibits translation in bat cells from Rhinolophus lepidus, belonging to the same genus as known sarbecovirus reservoirs hosts.

Dec 6, 2024 | cell.com | Kaitlin R Sprouse |Marcos Miranda |Nicholas J. Catanzaro |Amin Addetia |Cameron Stewart |Jack Brown | +19 more

KeywordsMERS-CoVEMPEMnanoparticlevaccineRBDNTDspikeResearch topic(s)CP: ImmunologyIntroductionThe recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has demonstrated the human and economic toll that can accompany the spillover and spread of a zoonotic disease in humans. Although the success of vaccine development efforts in response to the pandemic were a triumph of modern vaccinology, SARS-CoV-2 remains the only coronavirus for which licensed vaccines are available.

Apr 2, 2024 | biorxiv.org | Amin Addetia |Cameron Stewart |Albert J Seo |Kaitlin R Sprouse

AbstractMiddle-East respiratory syndrome coronavirus (MERS-CoV) first emerged in 2012 and causes human infections in endemic regions. Most vaccines and therapeutics in development against MERS-CoV focus on the spike (S) glycoprotein to prevent viral entry into target cells. These efforts, however, are limited by a poor understanding of antibody responses elicited by infection along with their durability, fine specificity and contribution of distinct S antigenic sites to neutralization.

Mar 14, 2024 | cell.com | M. Alejandra Tortorici |Amin Addetia |Albert J Seo |Jack Brown

Highlights•XBB.1.5 COVID-19 mRNA vaccine elicits neutralizing antibodies against current variants•Depletion of Wuhan-Hu-1 S-reactive plasma antibodies abrogate XBB.1.5 neutralization•XBB.1.5 COVID-19 mRNA vaccine primary recalls Wuhan-Hu-1 S-reactive memory B cellsSummaryImmune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains.

Mar 14, 2024 | shorturl.at | M. Alejandra Tortorici |Amin Addetia |Albert J Seo |Jack Brown

Highlights•XBB.1.5 COVID-19 mRNA vaccine elicits neutralizing antibodies against current variants•Depletion of Wuhan-Hu-1 S-reactive plasma antibodies abrogate XBB.1.5 neutralization•XBB.1.5 COVID-19 mRNA vaccine primary recalls Wuhan-Hu-1 S-reactive memory B cellsSummaryImmune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains.