Aleksandra A. Kolodziejczyk

May 22, 2023 | nature.com | Aaron Javitt |Merav D. Shmueli |Matthias P. Kramer |Aleksandra A. Kolodziejczyk |Kevin Litchfield |Adi Ulman | +7 more

AbstractImmunotherapy revolutionized treatment options in cancer, yet the mechanisms underlying resistance in many patients remain poorly understood. Cellular proteasomes have been implicated in modulating antitumor immunity by regulating antigen processing, antigen presentation, inflammatory signaling and immune cell activation. However, whether and how proteasome complex heterogeneity may affect tumor progression and the response to immunotherapy has not been systematically examined.