Matthias P. Kramer

Aug 25, 2024 | nature.com | Gal Aviel |Jacob Elkahal |Kfir Baruch Umansky |David Kain |Tali Shalit |Shoval Miyara | +2 more

AbstractMyocardial injury may ultimately lead to adverse ventricular remodeling and development of heart failure (HF), which is a major cause of morbidity and mortality worldwide. Given the slow pace and substantial costs of developing new therapeutics, drug repurposing is an attractive alternative. Studies of many organs, including the heart, highlight the importance of the immune system in modulating injury and repair outcomes.

May 22, 2023 | nature.com | Aaron Javitt |Merav D. Shmueli |Matthias P. Kramer |Aleksandra A. Kolodziejczyk |Kevin Litchfield |Adi Ulman | +7 more

AbstractImmunotherapy revolutionized treatment options in cancer, yet the mechanisms underlying resistance in many patients remain poorly understood. Cellular proteasomes have been implicated in modulating antitumor immunity by regulating antigen processing, antigen presentation, inflammatory signaling and immune cell activation. However, whether and how proteasome complex heterogeneity may affect tumor progression and the response to immunotherapy has not been systematically examined.