Alexander A. Merleev

2 months ago | insight.jci.org | JCI Insight |Stephanie Le |Alexander A. Merleev |Alina I. Marusina

AbstractNecrobiosis is a histologic term used to describe abnormal deposits of “degenerating” collagen within the skin. It can be found as an incidental finding in various granulomatous conditions, but is a hallmark of necrobiosis lipoidica (NL) and necrobiotic xanthogranuloma (NXG). There is limited prior research on necrobiosis. Here, we employed single-cell analysis of lesional and nonlesional skin to study the pathophysiology of necrobiosis.

Oct 26, 2023 | journals.plos.org | Michiko Shimoda |Tomoki Inagaki |Ryan Davis |Alexander A. Merleev |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article Citation: Shimoda M, Inagaki T, Davis RR, Merleev A, Tepper CG, Maverakis E, et al. (2023) Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages. PLoS Pathog 19(10): e1011703.