
Articles
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2 months ago |
insight.jci.org | JCI Insight |Stephanie Le |Alexander A. Merleev |Alina I. Marusina
AbstractNecrobiosis is a histologic term used to describe abnormal deposits of “degenerating” collagen within the skin. It can be found as an incidental finding in various granulomatous conditions, but is a hallmark of necrobiosis lipoidica (NL) and necrobiotic xanthogranuloma (NXG). There is limited prior research on necrobiosis. Here, we employed single-cell analysis of lesional and nonlesional skin to study the pathophysiology of necrobiosis.
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Sep 10, 2024 |
dx.doi.org | Stephanie Le |Prachi Gupta |Ranit Dutta |Jithu Krishna
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Aug 22, 2024 |
nature.com | Selene Lickfett |Agnieszka Rybak-Wolf |Carmen Menacho |Stephanie Le |Tancredi Massimo Pentimalli |Daniel Oehler | +14 more
AbstractExpansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we engineered male induced pluripotent stem cells to introduce a biallelic or monoallelic mutant 70Q expansion or to remove the poly-Q tract of HTT.
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May 13, 2024 |
agsjournals.onlinelibrary.wiley.com | Jeffrey Levine |Emily Samuels |Stephanie Le |Ruth Spinner
RESEARCH LETTER Pressure injuries and wound care: A lost geriatric syndrome Jeffrey M. Levine MD, AGSF, Corresponding Author Jeffrey M. Levine MD, AGSF Icahn School of Medicine at Mount Sinai, New York, New York, USA Correspondence Jeffrey M. Levine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Mar 22, 2024 |
cell.com | Stephanie Le |Heinrich Heine |Carmen Menacho |Alessandro Prigione
AbstractIn a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.
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