Alexander D Fulford

Nov 14, 2024 | biorxiv.org | Aashika Sekar |Alberto Rizzo |Alexander D Fulford |Elodie Sins

AbstractHippo signalling is an evolutionarily conserved pathway that regulates tissue growth. The FERM domain protein Expanded plays a crucial role in integrating polarity cues to activate the Hippo pathway. Previous work has shown that the apicobasal polarity protein Crumbs can limit Hippo activity by promoting the phosphorylation and degradation of Expanded. Here, we provide evidence that PP2AWrd can counteract the effects of Crumbs, by dephosphorylating and stabilising Expanded.

Feb 12, 2024 | biorxiv.org | Lauren Dawson |Alexander D Fulford |Aashika Sekar |Paulo Ribeiro

AbstractTissue growth is regulated by many signals, including polarity cues. The Hippo signalling pathway restricts tissue growth and receives inputs from the planar cell polarity-controlling Fat signalling pathway. The atypical cadherin Fat restricts growth via several mechanisms that ultimately control the activity of the pro-growth transcriptional co-activator Yorkie.

Jan 28, 2024 | biorxiv.org | Lauren Dawson |Paulo Ribeiro |Alexander D Fulford |Aashika Sekar

AbstractRegulation of tissue growth is influenced by many signals, including polarity cues. The Hippo signalling pathway restricts tissue growth and receives inputs from the planar cell polarity-controlling Fat signalling pathway. The atypical cadherin Fat restricts growth via several mechanisms that ultimately control the activity of the pro-growth transcriptional activator Yorkie.