Hannah Burgess

Feb 23, 2025 | nature.com | Lauren Dawson |Aashika Sekar |Alexander D Fulford |Rachel Lambert |Hannah Burgess

AbstractTissue growth is regulated by many signals, including polarity cues. The Hippo signalling pathway restricts tissue growth and receives inputs from the planar cell polarity-controlling Fat signalling pathway. The atypical cadherin Fat restricts growth via several mechanisms that ultimately control the activity of the pro-growth transcriptional co-activator Yorkie.