Alexander Hammermeister

May 14, 2024 | nature.com | Marcin Jaciuk |Alexander Rau |Alexander Hammermeister |Michał Rawski |Paulina Indyka |Urszula Jankowska | +7 more

AbstracttRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble uridine bases (cm5U34) in eukaryotic tRNAs. However, the structure and function of human Elongator remain poorly understood. In this study, we present a series of cryo-EM structures of human ELP123 in complex with tRNA and cofactors at four different stages of the reaction.