Marcin Jaciuk

Oct 3, 2024 | nature.com | Sebastian Pintscher |Rafał Pietras |Bohun Mielecki |Mateusz Szwalec |Anna Wójcik-Augustyn |Paulina Indyka | +3 more

AbstractA multi-subunit enzyme, cytochrome b6f (cytb6f), provides the crucial link between photosystems I and II in the photosynthetic membranes of higher plants, transferring electrons between plastoquinone (PQ) and plastocyanin. The atomic structure of cytb6f is known, but its detailed catalytic mechanism remains elusive.

May 14, 2024 | nature.com | Marcin Jaciuk |Alexander Rau |Alexander Hammermeister |Michał Rawski |Paulina Indyka |Urszula Jankowska | +7 more

AbstracttRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-carboxymethyl at wobble uridine bases (cm5U34) in eukaryotic tRNAs. However, the structure and function of human Elongator remain poorly understood. In this study, we present a series of cryo-EM structures of human ELP123 in complex with tRNA and cofactors at four different stages of the reaction.