Alexander Hunter

Jul 29, 2024 | bpspubs.onlinelibrary.wiley.com | Srinivas Kamath |UniSa Clinical |Alexander Hunter |Kate Collins

CD68 cluster of differentiation 68 ChREBP carbohydrate regulatory element binding protein F:B Firmicutes:Bacteroidetes LOQ limit of quantification OTU operational taxonomical unit PCoA principal coordinate analysis PUL polysaccharide utilisation loci SCFA short chain fatty acid SREBP-1c sterol-regulatory element binding protein 1c What is already known? Olanzapine induces weight gain by disrupting the gut microbiome.

Mar 3, 2024 | biorxiv.org | Srinivas Kamath |Alexander Hunter |Kate Collins |Anthony Wignall

AbstractAntipsychotics like olanzapine are associated with significant metabolic dysfunction, attributable to gut microbiota dysbiosis. A recent notion that most psychotropics are detrimental to the gut microbiota has arisen from consistent findings of metabolic adverse effects. However, unlike olanzapine, the metabolic effects of lurasidone are conflicting, with most reports observing weight loss rather than gain.