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Articles

The atypical antipsychotics lurasidone and olanzapine exert contrasting effects on the gut microbiome and metabolic function of rats

Jul 29, 2024 | bpspubs.onlinelibrary.wiley.com | Srinivas Kamath |UniSa Clinical |Alexander Hunter |Kate Collins

CD68 cluster of differentiation 68 ChREBP carbohydrate regulatory element binding protein F:B Firmicutes:Bacteroidetes LOQ limit of quantification OTU operational taxonomical unit PCoA principal coordinate analysis PUL polysaccharide utilisation loci SCFA short chain fatty acid SREBP-1c sterol-regulatory element binding protein 1c What is already known? Olanzapine induces weight gain by disrupting the gut microbiome.
A metabolome-wide Mendelian randomization study identifies dysregulated arachidonic acid synthesis as a potential causal risk factor for bipolar disorder

Feb 22, 2024 | biologicalpsychiatryjournal.com | David Stacey |UniSa Clinical |S Lee

AbstractBipolar disorder (BPD) is a debilitating mood disorder with an unclear aetiology. A better understanding of the underlying pathophysiological mechanisms will help to identify novel targets for improved treatment options and prevention strategies. In this metabolome-wide Mendelian randomization study, we screened for metabolites that may have a causal role in BPD. We tested a total of 913 circulating metabolite exposures assessed in 14,296 Europeans using a mass spectrometry-based platform.

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