UniSa Clinical

Jul 29, 2024 | bpspubs.onlinelibrary.wiley.com | Srinivas Kamath |UniSa Clinical |Alexander Hunter |Kate Collins

CD68 cluster of differentiation 68 ChREBP carbohydrate regulatory element binding protein F:B Firmicutes:Bacteroidetes LOQ limit of quantification OTU operational taxonomical unit PCoA principal coordinate analysis PUL polysaccharide utilisation loci SCFA short chain fatty acid SREBP-1c sterol-regulatory element binding protein 1c What is already known? Olanzapine induces weight gain by disrupting the gut microbiome.

Feb 22, 2024 | biologicalpsychiatryjournal.com | David Stacey |UniSa Clinical |S Lee

AbstractBipolar disorder (BPD) is a debilitating mood disorder with an unclear aetiology. A better understanding of the underlying pathophysiological mechanisms will help to identify novel targets for improved treatment options and prevention strategies. In this metabolome-wide Mendelian randomization study, we screened for metabolites that may have a causal role in BPD. We tested a total of 913 circulating metabolite exposures assessed in 14,296 Europeans using a mass spectrometry-based platform.

Mar 30, 2023 | ashpublications.org | UniSa Clinical

Once an appropriate sample type has been acquired, the next decision pertains to the type of technology to be used for testing. In many cases, there may be limited choices, influenced by regulatory, geographical, financial, and other aspects. A common starting point for many clinicians may be the use of NGS panels. As such, appropriate physical or virtual (eg, on the backbone of a whole-genome sequencing [WGS] platform) gene lists for diagnostic screening are a topic of much discussion.