Alexandra B Forman

Aug 23, 2024 | digitalcommons.library.tmc.edu | Clare Malone |Nathaniel W. Mabe |Alexandra B Forman |Gabriela Alexe

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN-amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic transcriptional program.