Nathaniel W. Mabe

Aug 23, 2024 | digitalcommons.library.tmc.edu | Clare Malone |Nathaniel W. Mabe |Alexandra B Forman |Gabriela Alexe

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN-amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic transcriptional program.

Jun 27, 2024 | nature.com | Nathaniel W. Mabe

AbstractEpigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including disease initiation, maintenance and therapy resistance. As a result, there have been advances in the development and evaluation of epigenetic therapies for cancer, revealing substantial promise but also challenges. Three epigenetic inhibitor classes are approved in the USA, and many more are currently undergoing clinical investigation.

May 31, 2024 | science.org | Youqi Yang |Qiancheng Xia |Clare Malone |Nathaniel W. Mabe

Research ArticleCANCERClare F. Malone https://orcid.org/0000-0002-1430-1774, Nathaniel W. Mabe https://orcid.org/0000-0003-2675-652X, [...] , Alexandra B. Forman https://orcid.org/0000-0002-9375-0446, Gabriela Alexe https://orcid.org/0000-0002-5668-6297, [...] , Kathleen L. Engel https://orcid.org/0000-0003-1426-0252, Ying-Jiun C. Chen https://orcid.org/0000-0002-6290-0771, Melinda Soeung https://orcid.org/0000-0002-6902-898X, Silvi Salhotra, Allen Basanthakumar, [...] , Bin Liu, Sharon Y. R.