Gabriela Alexe

Aug 23, 2024 | digitalcommons.library.tmc.edu | Clare Malone |Nathaniel W. Mabe |Alexandra B Forman |Gabriela Alexe

Pediatric cancers are frequently driven by genomic alterations that result in aberrant transcription factor activity. Here, we used functional genomic screens to identify multiple genes within the transcriptional coactivator Spt-Ada-Gcn5-acetyltransferase (SAGA) complex as selective dependencies for MYCN-amplified neuroblastoma, a disease of dysregulated development driven by an aberrant oncogenic transcriptional program.

Feb 16, 2024 | nature.com | Gabriela Alexe

Evasion of apoptosis is crucial for the growth, survival and chemoresistance of many cancer types, including acute myeloid leukemia (AML); thus, the reactivation of apoptosis can be exploited as a therapeutic approach. Apoptosis induction is mainly controlled by the balance between anti-apoptotic and pro-apoptotic BCL2 family proteins, which determines the oligomerization of effectors BAX and BAK and thus the permeabilization of mitochondrial membranes [1].