Alexandra Young

Jun 14, 2024 | nature.com | Sophie E Mastenbroek |Jacob Vogel |Lyduine E. Collij |Alexandra Young |Frederik Barkhof |Rik Ossenkoppele

AbstractLewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology.

Jan 8, 2024 | nature.com | Alexandra Young |Neil P. Oxtoby |Sara Garbarino |Frederik Barkhof

AbstractData-driven disease progression models are an emerging set of computational tools that reconstruct disease timelines for long-term chronic diseases, providing unique insights into disease processes and their underlying mechanisms. Such methods combine a priori human knowledge and assumptions with large-scale data processing and parameter estimation to infer long-term disease trajectories from short-term data.