Sophie E Mastenbroek

Jun 14, 2024 | nature.com | Sophie E Mastenbroek |Jacob Vogel |Lyduine E. Collij |Alexandra Young |Frederik Barkhof |Rik Ossenkoppele

AbstractLewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology.