Alexandrea K. Ramnarine

Nov 28, 2024 | nature.com | Yang Luo |Xin Wang |Qingyun Liu |Junhao Zhu |Roger Calderon |Sahadevan Raman | +4 more

AbstractInfectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.06, 95%CI: 4.87 − 20.77, P = 7.92 × 10−8) in the FLOT1 gene and a subclavaluee of Mtb Lineage 2.

Sep 30, 2024 | journals.plos.org | Jacob A. Mayfield |Vivek Mishra |Sahadevan Raman |Alexandrea K. Ramnarine

Citation: Mayfield JA, Raman S, Ramnarine AK, Mishra VK, Huang AD, Dudoit S, et al. (2024) Mycobacteria that cause tuberculosis have retained ancestrally acquired genes for the biosynthesis of chemically diverse terpene nucleosides. PLoS Biol 22(9): e3002813. https://doi.org/10.1371/journal.pbio.3002813Academic Editor: Tobias Bollenbach, Universitat zu Koln, GERMANYReceived: January 30, 2024; Accepted: August 24, 2024; Published: September 30, 2024Copyright: © 2024 Mayfield et al.