Alice Kennett

Apr 11, 2024 | pubs.rsc.org | Alice Kennett |Sven Epple |Irene Georgiou |Evelyne Gout

Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2) Correction for ‘Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)’ by Alice Kennett et al., Chem. Commun., 2024, 60, 436–439, https://doi.org/10.1039/D3CC02565A. This article is Open Access This article has not yet been cited.

Dec 12, 2023 | pubs.rsc.org | Alice Kennett |Sven Epple |Irene Georgiou |Evelyne Gout

Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)† Sulf-2 has been identified as a putative target for anticancer therapies. Here we report the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S). Trisulfated disaccharide inhibitor IdoA(2S)-GlcNS(6Sulfamate) demonstrated potent Sulf-2 inhibition.

Nov 7, 2023 | pubs.rsc.org | Sven Epple |Irene Georgiou |Evelyne Gout |Alice Kennett |Angela Russell

Modified minimal-size fragments of Heparan Sulfate as inhibitors of endosulfatase-2 (Sulf-2) Endosulfatase-2 (Sulf-2) has been identified as a putative target for anticancer therapeutics, however, the biological characterisation of this enzyme has been limited by the lack of potent, selective and easily synthesised inhibitors.