Alireza Ani

Oct 7, 2024 | nature.com | Julia Sidorenko |Kathryn E Kemper |Bjørn Olav Åsvold |Alireza Ani |Rujia Wang |Ilja M. Nolte | +13 more

AbstractLinkage studies have successfully mapped loci underlying monogenic disorders, but mostly failed when applied to common diseases. Conversely, genome-wide association studies (GWASs) have identified replicable associations between thousands of SNPs and complex traits, yet capture less than half of the total heritability.

Oct 6, 2023 | nature.com | Sonia Shah |Ilja M. Nolte |Alireza Ani

AbstractLow heart rate variability (HRV) has been widely reported as a predictor for increased mortality. However, the molecular mechanisms are poorly understood. Therefore, this study aimed to identify novel genetic loci associated with HRV and assess the association of phenotypic HRV and genetically predicted HRV with mortality.