Julia Sidorenko

Oct 7, 2024 | nature.com | Julia Sidorenko |Kathryn E Kemper |Bjørn Olav Åsvold |Alireza Ani |Rujia Wang |Ilja M. Nolte | +13 more

AbstractLinkage studies have successfully mapped loci underlying monogenic disorders, but mostly failed when applied to common diseases. Conversely, genome-wide association studies (GWASs) have identified replicable associations between thousands of SNPs and complex traits, yet capture less than half of the total heritability.

Sep 18, 2023 | nature.com | Adrian Campos |Shinichi Namba |Julia Sidorenko |Huanwei Wang |Seunggeun Lee |Yen-Feng Lin | +3 more

AbstractGenome-wide association studies (GWASs) have been mostly conducted in populations of European ancestry, which currently limits the transferability of their findings to other populations. Here, we show, through theory, simulations and applications to real data, that adjustment of GWAS analyses for polygenic scores (PGSs) increases the statistical power for discovery across all ancestries.