Amanda A. Heeren

Dec 19, 2023 | onlinelibrary.wiley.com | Xu Zhang |Amanda A. Heeren |Thomas White |Haojie Huang

BMDM Bone Marrow Derived Macrophages BMP Bone Morphogenetic Protein CCL The Chemokine (C-C motif) Ligand CXCL The chemokine (C-X-C motif) Ligand FAPs Fibroadipogenic Progenitors FGF Fibroblast Growth Factors GSEA Gene Set Enrichment Analysis IGF Insulin-like Growth Factor MK midkine ncWNT non-canonical WNT OPN Osteopontin SASP Senescence-Associated Secretory Phenotype SA-β-Gal Senescence-Associated Beta-Galactosidase scRNA-seq Single-Cell RNA-Sequencing 1 INTRODUCTION Fibroadipogenic...

Nov 14, 2023 | onlinelibrary.wiley.com | Zaira Aversa |Thomas White |Amanda A. Heeren |Cassondra A. Hulshizer

AL ad libitum BMI body mass index CALERIETM Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy CR calorie restriction GBM gradient boosting machine learning GSEA gene set enrichment analysis HOMA-IR homeostatic model assessment of insulin resistance ITT intention-to-treat NES normalized enrichment score RMR resting metabolic rate SASP senescence-associated secretory phenotype 1 INTRODUCTION Compelling evidence from a wide range of animal studies suggests that calorie...