Thomas White

Dec 19, 2023 | onlinelibrary.wiley.com | Xu Zhang |Amanda A. Heeren |Thomas White |Haojie Huang

BMDM Bone Marrow Derived Macrophages BMP Bone Morphogenetic Protein CCL The Chemokine (C-C motif) Ligand CXCL The chemokine (C-X-C motif) Ligand FAPs Fibroadipogenic Progenitors FGF Fibroblast Growth Factors GSEA Gene Set Enrichment Analysis IGF Insulin-like Growth Factor MK midkine ncWNT non-canonical WNT OPN Osteopontin SASP Senescence-Associated Secretory Phenotype SA-β-Gal Senescence-Associated Beta-Galactosidase scRNA-seq Single-Cell RNA-Sequencing 1 INTRODUCTION Fibroadipogenic...

Nov 14, 2023 | onlinelibrary.wiley.com | Zaira Aversa |Thomas White |Amanda A. Heeren |Cassondra A. Hulshizer

AL ad libitum BMI body mass index CALERIETM Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy CR calorie restriction GBM gradient boosting machine learning GSEA gene set enrichment analysis HOMA-IR homeostatic model assessment of insulin resistance ITT intention-to-treat NES normalized enrichment score RMR resting metabolic rate SASP senescence-associated secretory phenotype 1 INTRODUCTION Compelling evidence from a wide range of animal studies suggests that calorie...

Oct 6, 2023 | onlinelibrary.wiley.com | Susan A. Weston |Elizabeth Atkinson |Michelle M. Mielke |Thomas White

1 INTRODUCTION Cellular senescence is a mediator of aging and chronic disease (LeBrasseur et al., 2015). Diverse forms of age-related damage, including DNA lesions, mitochondrial dysfunction, proteotoxic aggregates, and inflammation converge on a common cellular fate of stable growth arrest, or senescence (Newgard & Sharpless, 2013).

Oct 2, 2023 | ophthalmologyscience.org | Alyssa L. Lie |Thomas White |Stony Brook

To investigate whether a redistribution of water within the crystalline lens is associated with the shape deformation that occurs during accommodation. Observational, cross sectional study. Eleven young adults without presbyopia (aged 18–39 years) and 9 middle-aged adults with presbyopia (aged 40–55 years). Magnetic resonance imaging (MRI) scans of the lens were acquired on a 3 Tesla clinical MRI scanner, without and with the presentation of a 3 Diopter accommodative stimulus.