Amrutha Kotlure

Jun 23, 2024 | biorxiv.org | Henry Michael Skelton |Dayton Grogan |Amrutha Kotlure |Ken Berglund

AbstractExercise is widely studied as a therapy in mouse models of neurological disease. However, the established techniques for exercise in mice are not ideally suited toward motor deficient disease models, nor do they facilitate active measurement of neurophysiology with tethered assays. To address this, we developed an apparatus and technique for inducing exercise in mice without aversive stimuli, using a motorized wheel with closed-loop acceleration that tracks subject performance.