Henry Michael Skelton

Sep 20, 2024 | biorxiv.org | Henry Michael Skelton |Nathaniel Hyman |Alejandra Fernandez |Alejandra Fernández |Emma ACERBO

AbstractExercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that has been demonstrated in animal models. While this preclinical work has provided insight into the underlying molecular mechanisms, it has not addressed the neurophysiological changes during exercise. Here, first, we tested for neuroprotective effects of adaptive wheel exercise in the 6-hydroxydopamine mouse model of Parkinson's disease.

Jun 23, 2024 | biorxiv.org | Henry Michael Skelton |Dayton Grogan |Amrutha Kotlure |Ken Berglund

AbstractExercise is widely studied as a therapy in mouse models of neurological disease. However, the established techniques for exercise in mice are not ideally suited toward motor deficient disease models, nor do they facilitate active measurement of neurophysiology with tethered assays. To address this, we developed an apparatus and technique for inducing exercise in mice without aversive stimuli, using a motorized wheel with closed-loop acceleration that tracks subject performance.