Ken Berglund

Jun 23, 2024 | biorxiv.org | Henry Michael Skelton |Dayton Grogan |Amrutha Kotlure |Ken Berglund

AbstractExercise is widely studied as a therapy in mouse models of neurological disease. However, the established techniques for exercise in mice are not ideally suited toward motor deficient disease models, nor do they facilitate active measurement of neurophysiology with tethered assays. To address this, we developed an apparatus and technique for inducing exercise in mice without aversive stimuli, using a motorized wheel with closed-loop acceleration that tracks subject performance.

Sep 29, 2023 | biorxiv.org | Matthew Stern |Eric Cole |Robert Gross |Ken Berglund

AbstractSignificance: Genetic cellular calcium imaging has emerged as a powerful tool to investigate how different types of neurons interact at the microcircuit level to produce seizure activity, with newfound potential to understand epilepsy. Although many methods exist to measure seizure-related activity in traditional electrophysiology, few yet exist for calcium imaging.

Jun 28, 2023 | frontiersin.org | Maria Mola |Hyungju Park |Ken Berglund

IntroductionOptogenetics is an innovative technology for controlling the complex nervous system, allowing for two-way interactions between neurons and glial cells. Numerous studies have shown that optogenetic treatment of neuronal cells promotes cell excitability (Adamantidis et al., 2007; Carter et al., 2010; Park et al., 2015; Hyung et al., 2019) and synaptic response (Lindsay et al., 2011; Mahn et al., 2016; Sinnen et al., 2017).