Amy Cain

Apr 18, 2024 | onlinelibrary.wiley.com | Siyuan Zhuang |Lucie Semenec |Stephanie S. Nagy |Amy Cain

1 INTRODUCTION Flow cytometry (FC) is universally recognized as a powerful technique for single-cell interrogation, enabling high-throughput quantitative assays of cellular phenotypes [1, 2] and activities [3].

Oct 9, 2023 | nature.com | Liping Li |Francesca L. Short |Karl A. Hassan |Stephanie S. Nagy |Bhumika S. Shah |Nusrat Afrin | +2 more

AbstractConcerns exist that widespread use of antiseptic or disinfectant biocides could contribute to the emergence and spread of multidrug-resistant bacteria. To investigate this, we performed transposon-directed insertion-site sequencing (TraDIS) on the multidrug-resistant pathogen, Acinetobacter baumannii, exposed to a panel of ten structurally diverse and clinically relevant biocides.

Feb 9, 2023 | nature.com | Lucie Semenec |Amy Cain |Catherine J. Dawson |Anahit Penesyan |Francesca L. Short |Karl A. Hassan | +1 more

AbstractAcinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens frequently co-isolated from polymicrobial infections. The infections where these pathogens co-exist can be more severe and recalcitrant to therapy than infections caused by either species alone, however there is a lack of knowledge on their potential synergistic interactions. In this study we characterise the genomes of A. baumannii and K. pneumoniae strains co-isolated from a single human lung infection.