Andre Franke

Feb 12, 2025 | nature.com | Johannes Hertel |Stefan Weiss |Malte Christoph Rühlemann |Corinna Bang |Andre Franke |Uwe Völker | +12 more

Sedentarism is characterized by low levels of physical activity, a risk factor for obesity and cardio-metabolic diseases. It can also adversely affect the composition and diversity of the gut microbiome which may result in harmful consequences for human health. While cardiorespiratory fitness (CRF) is inversely and independently associated with cardiovascular risk factors and diseases and all-cause mortality, the relationship between low CRF and the gut microbiome is not well known. A total of 3,616 individuals from two independent population-based cohorts of the Study of Health in Pomerania (SHIP-START and SHIP-TREND) performed standardized, symptom-limited cardiopulmonary exercise testing (CPET) and had faecal samples collected to determine gut microbiota profiles (16S rRNA gene sequencing). We analysed cross-sectional associations of CRF with the gut microbiome composition controlling for confounding factors. Lower CRF was associated with reduced microbial diversity, loss of beneficial short-chain fatty acid producing bacteria (i.e. Butyricoccus, Coprococcus, unclassified Ruminococcaceae or Lachnospiraceae) and an increase in opportunistic pathogens such as Escherichia/Shigella, or Citrobacter. Decreased cardiorespiratory performance was associated with a gut microbiota pattern that has been previously related to a proinflammatory state. These associations were independent of body weight or glycemic control.

Jul 11, 2024 | gut.bmj.com | Simonas Juzenas |David Ellinghaus |Serena Sanna |Andre Franke

X @SimonasJuzenas, @damato_mauroContributors SS, AF and MD designed and supervised the study; SJ and DE contributed to data acquisition, statistical and computational analyses; SJ, DE, SS, AF and MD analysed and interpreted data; SJ and MD drafted the manuscript, with input and critical revision from all other authors. All authors approved the final draft of the manuscript. Funding The study received funds through AF’s grantFR 2821/19-1 from the German Research Foundation (DFG).

Jun 5, 2024 | nature.com | Barbara Schormair |Steven Bell |Maria Didriksen |Ambra Stefani |Georgios M. Hadjigeorgiou |Owen A Ross | +16 more

AbstractRestless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X.

Oct 9, 2023 | gut.bmj.com | Simonas Juzenas |David Ellinghaus |Serena Sanna |Andre Franke

Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.