Uwe Völker

Feb 12, 2025 | nature.com | Johannes Hertel |Stefan Weiss |Malte Christoph Rühlemann |Corinna Bang |Andre Franke |Uwe Völker | +12 more

Sedentarism is characterized by low levels of physical activity, a risk factor for obesity and cardio-metabolic diseases. It can also adversely affect the composition and diversity of the gut microbiome which may result in harmful consequences for human health. While cardiorespiratory fitness (CRF) is inversely and independently associated with cardiovascular risk factors and diseases and all-cause mortality, the relationship between low CRF and the gut microbiome is not well known. A total of 3,616 individuals from two independent population-based cohorts of the Study of Health in Pomerania (SHIP-START and SHIP-TREND) performed standardized, symptom-limited cardiopulmonary exercise testing (CPET) and had faecal samples collected to determine gut microbiota profiles (16S rRNA gene sequencing). We analysed cross-sectional associations of CRF with the gut microbiome composition controlling for confounding factors. Lower CRF was associated with reduced microbial diversity, loss of beneficial short-chain fatty acid producing bacteria (i.e. Butyricoccus, Coprococcus, unclassified Ruminococcaceae or Lachnospiraceae) and an increase in opportunistic pathogens such as Escherichia/Shigella, or Citrobacter. Decreased cardiorespiratory performance was associated with a gut microbiota pattern that has been previously related to a proinflammatory state. These associations were independent of body weight or glycemic control.

Oct 9, 2024 | jme.bioscientifica.com | Uwe Völker

Robin Haring Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine Search for other papers by Robin Haring in Google Scholar PubMed Close , Henri Wallaschofski Institute of Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, Department of Pharmacology, School of Clinical and Experimental Medicine Search...

Aug 19, 2024 | nature.com | Anna Halama |Shaza B. Zaghlool |Gaurav Thareja |Wadha Al Muftah |Sabine Ameling |Maja Pucic Baković | +8 more

AbstractIn-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes Qatar Metabolomics Study of Diabetes (QMDiab).