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Dec 5, 2024 | 
nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
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Nov 29, 2024 | 
jech.bmj.com | G David Batty |Steven Bell |Urho M Kujala |Seppo Sarna
Health characteristics and health behaviours in male former contact sports participants: comparison with general population controls in a Finnish cohort study Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Nov 27, 2024 | 
jech.bmj.com | G David Batty |Steven Bell |Urho M Kujala |Seppo Sarna
Health characteristics and health behaviours in male former contact sports participants: omparison with general population controls in a Finnish cohort study Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Jun 5, 2024 | 
nature.com | Barbara Schormair |Steven Bell |Maria Didriksen |Ambra Stefani |Georgios M. Hadjigeorgiou |Owen A Ross | +16 more
AbstractRestless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X.
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May 9, 2024 | 
jech.bmj.com | Steven Bell
Nucleus of fairness: epigenetic ageing, social determinants of health and the imperative for proactive preventive measures Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Dec 13, 2023 | 
nature.com | Pek Kei Im |Anya Topiwala |Zhengming Chen |Iona Y. Millwood |Steven Bell
AbstractAlcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank.
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Oct 12, 2023 | 
jech.bmj.com | Steven Bell
Nucleus of fairness: epigenetic ageing, social determinants of health and the imperative for proactive preventive measures Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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May 16, 2023 | 
milanofinanza.it | Steven Bell
Attualmente il consenso economico vede un aumento del rischio di recessione negli Stati Uniti e una riduzione del medesimo rischio nel Regno Unito e nell'Eurozona. Si tratta di un grande cambiamento rispetto all'inizio dell'anno, quando la probabilità di recessione nei successivi 12 mesi era stimata a un notevole 90% nel Regno Unito, all'80% in Europa e al 60% negli Stati Uniti. La...
