Andrea Nieto-Aliseda

Mar 31, 2024 | nature.com | François Serra |Andrea Nieto-Aliseda |Andrei L. Okorokov |Peter Fraser |Mariona Graupera |Sandra D Castillo | +3 more

AbstractActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the critical role of spatio-temporal genome architecture in this process.