François Serra

Featured in: Favicon

Articles

p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response - Nature Communications

Mar 31, 2024 | nature.com | François Serra |Andrea Nieto-Aliseda |Andrei L. Okorokov |Peter Fraser |Mariona Graupera |Sandra D Castillo | +3 more

AbstractActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the critical role of spatio-temporal genome architecture in this process.
The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer - Nature Communications

Dec 6, 2023 | nature.com | François Serra |Iker Núñez-Carpintero |Stefano Gustincich |Alfonso Valencia |Matthew Freedman |Claudia Giambartolomei

AbstractWe introduce Promoter-Enhancer-Guided Interaction Networks (PENGUIN), a method for studying protein-protein interaction (PPI) networks within enhancer-promoter interactions. PENGUIN integrates H3K27ac-HiChIP data with tissue-specific PPIs to define enhancer-promoter PPI networks (EPINs). We validated PENGUIN using cancer (LNCaP) and benign (LHSAR) prostate cell lines.

Try JournoFinder For Free

Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.