Mariona Graupera

Aug 20, 2024 | nature.com | Sarah E. Conduit |Laura Bozal-Basterra |Mathias Cobbaut |Sandra D Castillo |Arkaitz Carracedo |Mariona Graupera | +5 more

AbstractPrimary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly.

Mar 31, 2024 | nature.com | François Serra |Andrea Nieto-Aliseda |Andrei L. Okorokov |Peter Fraser |Mariona Graupera |Sandra D Castillo | +3 more

AbstractActivation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood. Here, we uncover the critical role of spatio-temporal genome architecture in this process.