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Dec 1, 2024 | 
nature.com | Andres M. Lozano |Andrés Lozano
AbstractIdiopathic Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive surgical option. This study assesses the safety and efficacy of unilateral MRgFUS subthalamotomy, aiming to create the smallest effective lesion.
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Nov 21, 2024 | 
scholarsarchive.byu.edu | Christopher Dromey |Rajeev Kumar |Anthony E Lang |Andres M. Lozano |Andrés Lozano
Deep brain stimulation, functional neurosurgery, parkinson's disease, speech, subthalamic nucleusDromey, C., Kumar, R., Lang, A., & Lozano, A. (2000). An investigation of the effects of subthalamic nucleus stimulation on acoustic measures of voice. Movement Disorders, 15, 1132-1138. Dromey, Christopher; Kumar, Rajeev; Lang, Anthony E.; and Lozano, Andres M., "An Investigation of the Effects of Subthalamic Nucleus Stimulation on Acoustic Measures of Voice" (2000). Faculty Publications. 7277.
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Oct 30, 2024 | 
jneurosci.org | Andrew Yang |Stephanie Tran |Andres M. Lozano |Andrés Lozano |Robert Chen
Investigation of Metaplasticity Associated with Transcranial Focused Ultrasound Neuromodulation in Humans Mandy Yi Rong Ding, Tarun Arora, Can Sarica, Andrew Z. Yang, Negar Nasrkhani, Talyta Grippe, Jean-François Nankoo, Stephanie Tran, Nardin Samuel, Xue Xia, Andres M. Lozano, Robert Chen Journal of Neuroscience 30 October 2024, 44 (44) e2438232024; DOI: 10.1523/JNEUROSCI.2438-23.2024
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Oct 1, 2024 | 
thejns.org | Andres M. Lozano |Andrés Lozano |Ellen L. Air |Gordon H. Baltuch |Francisco Ponce
Correspondence Andres M. Lozano: [email protected]. INCLUDE WHEN CITING DOI: 10.3171/2024.7.FOCVID23220Disclosures Dr. Lozano reported consulting fees from Abbott, Boston Scientific, Insightec, and Medtronic; and personal fees (scientific director) from Functional Neuromodulation. Dr. Air reported research fees from Medtronic; and personal fees from Enspire DBS, Functional Neuromodulation, Stryker, and Setpoint.
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Sep 11, 2024 | 
nature.com | Srdjan Sumarac |Mojgan Hodaie |Andres M. Lozano |Andrés Lozano |William Hutchison |Alfonso Fasano
AbstractParkinson’s disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores.
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Sep 11, 2024 | 
jneurosci.org | Andrew Yang |Stephanie Tran |Andres M. Lozano |Andrés Lozano |Robert Chen
AbstractLow intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for non-invasive brain stimulation (NIBS). TUS delivered in a theta (5Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30-60 minutes, showing promise for therapeutic development.
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May 8, 2024 | 
tandfonline.com | Christian Iorio-Morin |David Mathieu |Andrea Franzini |Andres M. Lozano |Andrés Lozano
ABSTRACTIntroduction Essential tremor (ET) is the most frequent movement disorder, affecting up to 5% of adults > 65 years old. In 30–50% of cases, optimal medical management provides insufficient tremor relief and surgical options are considered. Thalamotomy is a time-honored intervention, which can be performed using radiofrequency (RF), stereotactic radiosurgery (SRS), or magnetic resonance-guided focused ultrasounds (MRgFUS).
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Apr 11, 2024 | 
nature.com | Srdjan Sumarac |Jürgen Germann |Milos R. Popovic |Mojgan Hodaie |Alfonso Fasano |Andres M. Lozano | +2 more
AbstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy. However, the single-neuron and synaptic bases of ERNA are unsubstantiated. This study proposes that ERNA is a subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network.
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Nov 22, 2023 | 
mdpi.com | Andres M. Lozano |Andrés Lozano |Josué Pino |Ignacio Moreno-Torres |Rosa Bermúdez
1. IntroductionHypernasality is a speech condition in which the speaker produces nasal sounds while attempting to produce oral ones [1]. Hypernasality may occur due to anatomic malformations (e.g., cleft palate) that let the air in the mouth cavity scape towards the nose cavity, or due to the lack of precise motor skills that result in patients failing to lower the velum [2].
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Jun 9, 2023 | 
tandfonline.com | Andres M. Lozano |Andrés Lozano
ABSTRACTIntroduction Essential Tremor (ET) is one of the most common tremor syndromes typically presented as action tremor, affecting mainly the upper limbs. In at least 30–50% of patients, tremor interferes with quality of life, does not respond to first-line therapies and/or intolerable adverse effects may occur. Therefore, surgery may be considered.
