Andrew Hamel

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Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma - Nature Communications

Jan 9, 2024 | nature.com | Andrew Hamel |Wenjun Yan |Xinyi Jiang |Qingnan Liang |Sreekar Mantena |Jiali Wang | +11 more

AbstractPrimary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP.

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