Qingnan Liang

Mar 21, 2024 | biorxiv.org | Qingnan Liang |Luisa Solis Soto |Cara Haymaker |Ken Chen

AbstractCellular anatomy and signaling vary across niches, which can induce gradated gene expressions in subpopulations of cells. Such spatial transcriptomic gradient (STG) makes a significant source of intra-tumor heterogeneity and can influence tumor invasion, progression, and response to treatment.

Jan 9, 2024 | nature.com | Andrew Hamel |Wenjun Yan |Xinyi Jiang |Qingnan Liang |Sreekar Mantena |Jiali Wang | +11 more

AbstractPrimary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP.