Sreekar Mantena

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Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection - Nature Biotechnology

Oct 11, 2024 | nature.com | Sreekar Mantena |Brittany A. Petros |Cameron Myhrvold |Pardis Sabeti

AbstractCRISPR guide RNA sequences deriving exactly from natural sequences may not perform optimally in every application. Here we implement and evaluate algorithms for designing maximally fit, artificial CRISPR–Cas13a guides with multiple mismatches to natural sequences that are tailored for diagnostic applications.
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma - Nature Communications

Jan 9, 2024 | nature.com | Andrew Hamel |Wenjun Yan |Xinyi Jiang |Qingnan Liang |Sreekar Mantena |Jiali Wang | +11 more

AbstractPrimary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP.

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