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2 months ago | 
nature.com | Danielle Rasooly |Claudia Giambartolomei |Gina M. Peloso |Maik Pietzner |Eric Farber-Eger |Lawrence Phillips | +4 more
AbstractHeart failure (HF) has limited therapeutic options. In this study, we differentiated the pathophysiological underpinnings of the HF subtypes—HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF)—and uncovered subtype-specific therapeutic strategies. We investigated the causal roles of the human proteome and transcriptome using Mendelian randomization on more than 420,000 participants from the Million Veteran Program (27,799 HFrEF and 27,579 HFpEF cases).
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Aug 29, 2024 | 
architectureau.com | Andrew Leach
When the house designed by Peter (R. N.) Johnson for his family was placed on the market in 2009, genuine prospective buyers found themselves surrounded by those keen for a look at a house they already knew. Many had seen pictures and drawings of this anchor of Sydney’s modern architectural history. A few had, as students, even been introduced to it in real life by its architect, when he was their teacher.
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Jul 4, 2024 | 
nature.com | Aled Edwards |Ola Engkvist |David G. Hulcoop |Andrew Leach |Brian D. Marsden |Amelie Menge | +10 more
AbstractThe Structural Genomics Consortium is an international open science research organization with a focus on accelerating early-stage drug discovery, namely hit discovery and optimization. We, as many others, believe that artificial intelligence (AI) is poised to be a main accelerator in the field. The question is then how to best benefit from recent advances in AI and how to generate, format and disseminate data to enable future breakthroughs in AI-guided drug discovery.
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Jun 24, 2024 | 
architectureau.com | Andrew Leach
It was not the first time I had encountered a project by Matthew Eagle and his practice ME for clients Libby and Josh Brady. This new renovation in the southern Gold Coast suburb of Currumbin followed a new build on the edge of the nearby Currumbin Valley that I had reviewed a few years earlier (Tierney Drive House, see Houses 128).
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Apr 9, 2024 | 
leach.substack.com | Andrew Leach
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Mar 12, 2024 | 
country-guide.ca | Andrew Leach
Family ties and farming operations have long been intertwined. Indeed, family forms the backbone of many of our agricultural traditions, and today, it is often the reason why navigating farm succession is so complex. Read AlsoChoosing who gets to rent your farmlandFor Robert Andjelic, the largest farmland owner in Canada, this has become the top priority when he’s looking to decide…In fact, we can say even more.
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Feb 22, 2024 | 
theglobeandmail.com | Andrew Leach
Open this photo in gallery:Saskatchewan Premier Scott Moe stands beside Prime Minister Justin Trudeau during an announcement at Dene High School in La Loche, Sask., on Jan. 23, 2019.Kayle Neis/The Canadian PressPlease log in to bookmark this story.Log InCreate Free AccountAndrew Leach is a professor of law and economics and co-director of the Institute for Public Economics at the University of Alberta.
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Jan 22, 2024 | 
open.substack.com | Andrew Leach
By: Andrew LeachOn Thursday, January 11th, Alberta set an all-time record for electricity use. Alberta’s hourly demand peaked at 12,384MW, beating the 12,193MW record set in December of 2022. There were no emergency alerts regarding the electricity market that day. No grid alerts were called, nor were panicked calls made for exports from Saskatchewan or B.C. You probably didn’t even know it had happened. Why?
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Jan 12, 2024 | 
leach.substack.com | Andrew Leach
It’s been a day of chaos in energy markets in Western Canada. The effect of a vicious cold snap has ravaged gas and electricity markets. In gas markets, supply issues caused by freeze-ups along with the really high heating loads due to the current cold snap appear to have been behind curtailment on the Nova system. Below, you can see the list of bulletins issued, mostly for the Foothills system, through the day today.
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Jan 12, 2024 | 
leach.substack.com | Andrew Leach
It’s been a day of chaos in energy markets in Western Canada. The effect of a vicious cold snap has ravaged gas and electricity markets. In gas markets, supply issues caused by freeze-ups along with the really high heating loads due to the current cold snap appear to have been behind curtailment on the Nova system. Below, you can see the list of bulletins issued, mostly for the Foothills system, through the day today.
