Andrew Tran

Sep 12, 2024 | pubs.acs.org | Kamal Bhatt |Alafate Adili |Andrew Tran |Kamal M. Elmallah

IntroductionClick to copy section linkSection link copied!Azacycles are privileged scaffolds of great importance in drug discovery and natural product chemistry. (1) The need to access these materials in an efficient fashion has stimulated the development of numerous synthetic methodologies, (2) particularly those involving C–H bond functionalization.

Aug 28, 2024 | jamanetwork.com | Andrew Tran |Lisa Gelles

A 1-day-old, healthy, full-term boy born by cesarean delivery for placental abruption to a 31-year-old primigravid mother was noted at birth to have an erythematous patch on his lower lip. This asymptomatic lesion did not interfere with his ability to feed. Physical examination showed a well-appearing infant without evidence of asymmetry, overgrowth, or digital anomalies.

Feb 9, 2024 | biorxiv.org | Xiangru Tang |Andrew Tran |Jeffrey Tan |Mark Gerstein

AbstractThe current paradigm of deep learning models for the joint representation of molecules and text primarily relies on 1D or 2D molecular formats, neglecting significant 3D structural information that offers valuable physical insight. This narrow focus inhibits the models' versatility and adaptability across a wide range of modalities. Conversely, the limited research focusing on explicit 3D representation tends to overlook textual data within the biomedical domain.

Jan 12, 2024 | pubs.acs.org | Noah B Bissonnette |Niels Bisballe |Andrew Tran |James A Rossi-Ashton

Here we report the design of a general, redox-switchable organophosphorus alkyl radical trap that enables the synthesis of a broad range of C(sp3)–P(V) modalities. This “plug-and-play” approach relies upon in situ activation of alcohols and O═P(R2)H motifs, two broadly available and inexpensive sources of molecular complexity.

Jan 12, 2024 | dx.doi.org | Noah B Bissonnette |Andrew Tran |James A Rossi-Ashton |Niels Bisballe

Here we report the design of a general, redox-switchable organophosphorus alkyl radical trap that enables the synthesis of a broad range of C(sp3)–P(V) modalities. This “plug-and-play” approach relies upon in situ activation of alcohols and O═P(R2)H motifs, two broadly available and inexpensive sources of molecular complexity.