Andrew Ward

Nov 4, 2024 | nature.com | Laura Spector |Wei Qing Wang |Pietro Sormanni |Monica L. Fernández-Quintero |Andrew Ward |Charlotte M. Deane | +7 more

Science is frequently subject to the Gartner hype cycle1: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology.

Sep 26, 2024 | cell.com | Andrew Ward |Charlotte M. Deane

Keywordsstructure predictionconformational ensemble predictionmolecular dynamics simulationsmachine learningantibodiesproteasesNMRX-rayprotein free energy landscapesGet full text accessLog in, subscribe or purchase for full access. References1. Jumper, J. ∙ Evans, R. ∙ Pritzel, A. ... Highly accurate protein structure prediction with AlphaFoldNature. 2021; 596:583-5892. Pereira, J. ∙ Simpkin, A.J. ∙ Hartmann, M.D. ... High-accuracy protein structure prediction in CASP14Proteins. 2021; 89:1687-16993.

Jun 14, 2024 | nature.com | Ivy Phung |Olivia K. Swanson |Chang-Chun D. Lee |Ester Marina-Zárate |Gabriel Ozorowski |Kimmo Rantalainen | +28 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01833-w, published online 30 May 2024In the version of the article initially published, Steven Schultze’s surname appeared incorrectly (as Schulze) and has now been amended in the HTML and PDF versions of the article.

May 30, 2024 | nature.com | Ivy Phung |Olivia K. Swanson |Chang-Chun D. Lee |Ester Marina-Zárate |Gabriel Ozorowski |Kimmo Rantalainen | +28 more

AbstractA key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of priming immunogens that induce rare bnAb-precursor B cells.

Feb 5, 2024 | nature.com | James Ferguson |Andrew Ward

Antigen reorientation via oligoD, a label-free, alum-based technique, guides immunofocused, broadly reactive antibody responses. Alum adjuvants work by binding to the protein antigen via electrostatic interactions, improving antigen uptake while inducing a type 2 helper T cell-type immune response7.