Charlotte M. Deane

Nov 4, 2024 | nature.com | Laura Spector |Wei Qing Wang |Pietro Sormanni |Monica L. Fernández-Quintero |Andrew Ward |Charlotte M. Deane | +7 more

Science is frequently subject to the Gartner hype cycle1: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology.

Sep 26, 2024 | cell.com | Andrew Ward |Charlotte M. Deane

Keywordsstructure predictionconformational ensemble predictionmolecular dynamics simulationsmachine learningantibodiesproteasesNMRX-rayprotein free energy landscapesGet full text accessLog in, subscribe or purchase for full access. References1. Jumper, J. ∙ Evans, R. ∙ Pritzel, A. ... Highly accurate protein structure prediction with AlphaFoldNature. 2021; 596:583-5892. Pereira, J. ∙ Simpkin, A.J. ∙ Hartmann, M.D. ... High-accuracy protein structure prediction in CASP14Proteins. 2021; 89:1687-16993.

Jul 1, 2023 | biorxiv.org | Oliver Turnbull |Annabel Suter |Bora Guloglu |Charlotte M. Deane

New Results doi: https://doi.org/10.1101/2023.06.28.546839 AbstractAntibodies with lambda light chains (lambda-antibodies) are generally considered to be less developable than those with kappa light chains (kappa-antibodies), leading to substantial systematic biases in drug discovery pipelines. This has contributed to kappa dominance amongst clinical-stage therapeutics.

Jun 30, 2023 | biorxiv.org | Oliver Turnbull |Annabel Suter |Bora Guloglu |Charlotte M. Deane

New Results doi: https://doi.org/10.1101/2023.06.28.546839 AbstractAntibodies with lambda light chains (lambda-antibodies) are generally considered to be less developable than those with kappa light chains (kappa-antibodies), leading to substantial systematic biases in drug discovery pipelines. This has contributed to kappa dominance amongst clinical-stage therapeutics.