Charlotte M. Deane

Nov 4, 2024 | nature.com | Laura Spector |Wei Qing Wang |Pietro Sormanni |Monica L. Fernández-Quintero |Andrew Ward |Charlotte M. Deane | +7 more

Science is frequently subject to the Gartner hype cycle1: emergent technologies spark intense initial enthusiasm with the recruitment of dedicated scientists. As limitations are recognized, disillusionment often sets in; some scientists turn away, disappointed in the inability of the new technology to deliver on initial promise, while others persevere and further develop the technology.

Sep 26, 2024 | cell.com | Andrew Ward |Charlotte M. Deane

Keywordsstructure predictionconformational ensemble predictionmolecular dynamics simulationsmachine learningantibodiesproteasesNMRX-rayprotein free energy landscapesGet full text accessLog in, subscribe or purchase for full access. References1. Jumper, J. ∙ Evans, R. ∙ Pritzel, A. ... Highly accurate protein structure prediction with AlphaFoldNature. 2021; 596:583-5892. Pereira, J. ∙ Simpkin, A.J. ∙ Hartmann, M.D. ... High-accuracy protein structure prediction in CASP14Proteins. 2021; 89:1687-16993.

Jul 1, 2023 | biorxiv.org | Oliver Turnbull |Annabel Suter |Bora Guloglu |Charlotte M. Deane

New Results doi: https://doi.org/10.1101/2023.06.28.546839 AbstractAntibodies with lambda light chains (lambda-antibodies) are generally considered to be less developable than those with kappa light chains (kappa-antibodies), leading to substantial systematic biases in drug discovery pipelines. This has contributed to kappa dominance amongst clinical-stage therapeutics.

Jun 30, 2023 | biorxiv.org | Oliver Turnbull |Annabel Suter |Bora Guloglu |Charlotte M. Deane

New Results doi: https://doi.org/10.1101/2023.06.28.546839 AbstractAntibodies with lambda light chains (lambda-antibodies) are generally considered to be less developable than those with kappa light chains (kappa-antibodies), leading to substantial systematic biases in drug discovery pipelines. This has contributed to kappa dominance amongst clinical-stage therapeutics.

May 18, 2023 | biorxiv.org | Bora Guloglu |Charlotte M. Deane

New Results doi: https://doi.org/10.1101/2023.05.16.540974 AbstractAntibodies, through their ability to target virtually any epitope, play a key role in driving the adaptive immune response in jawed vertebrates. The binding domains of standard antibodies are their variable light (VL) and heavy (VH) domains, both of which present analogous complementarity-determining region (CDR) loops.