Andrey Poleshko

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A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation - Nature Cardiovascular Research

Feb 22, 2024 | nature.com | Arun Padmanabhan |Angelo Pelonero |Tomohiro Nishino |Lin Ye |Andrey Poleshko |Michael Alexanian | +2 more

AbstractHuman induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in a hiPSC to CM differentiation system and reveal here that BRD4, a member of the bromodomain and extraterminal (BET) family, regulates CM differentiation.

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