Michael Alexanian

Oct 23, 2024 | nature.com | Michael Alexanian |Tomohiro Nishino |Lin Ye |Clara Lee |Will Flanigan |Zachary Gardner | +7 more

AbstractChronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel maladaptive cell state transitions1 and pathological interaction between cellular compartments.

Feb 22, 2024 | nature.com | Arun Padmanabhan |Angelo Pelonero |Tomohiro Nishino |Lin Ye |Andrey Poleshko |Michael Alexanian | +2 more

AbstractHuman induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in a hiPSC to CM differentiation system and reveal here that BRD4, a member of the bromodomain and extraterminal (BET) family, regulates CM differentiation.

Nov 29, 2023 | nature.com | Angelo Pelonero |Lin Ye |Michael Alexanian |Frances Koback |Casey A. Gifford

AbstractMaternal diabetes mellitus is among the most frequent environmental contributors to congenital birth defects, including heart defects and craniofacial anomalies, yet the cell types affected and mechanisms of disruption are largely unknown. Here, using multimodal single-cell analyses, we show that maternal diabetes affects the epigenomic landscape of specific subsets of cardiac and craniofacial progenitors during embryogenesis.